There were no differences in functional outcome scores between groups. Approximately 3.4 and 1.6% of patients in the high- and low-dose groups, respectively, had mild transient hypercalcemia, but none developed moderate, severe, or symptomatic hypercalcemia. The high-dose group had a higher rate of serum 25(OH)D restoration to optimal level than the low-dose group (82.8% vs 52.5%, respectively p < 0.001). The remaining 119 patients (58 and 61 in the high- and low-dose groups, respectively) were included in the final analysis. Of the 140 patients who were enrolled, 21 patients were lost to follow-up during the study period. The number of patients who achieved optimal vitamin D level (serum 25(OH)D > 30 ng/mL), the proportion of patients who developed hypercalcemia, and the functional outcome were compared between groups.
MethodsĪ total of 140 patients diagnosed with fragility hip fracture were randomly allocated to either the high-dose (60,000 IU/week) or low-dose (20,000 IU/week) vitamin D2 supplementation group for 12 weeks.
The aim of this study was to evaluate the effectiveness and safety of vitamin D supplementation in fragility hip fracture patients compared between high- and low-dose vitamin D supplementation.
Without the baseline serum 25(OH)D level, the appropriate dose of vitamin D supplementation is not known. However, measurement of 25-hydroxyvitamin D (25(OH)D) level is costly and may not be available in some centers. The tablets are available on prescription, or you can buy them without a prescription at a pharmacy.Hypovitaminosis D can be observed in most fragility hip fracture patients. You will be recommended to take a supplement such as calcium and ergocalciferol tablets routinely. Your body needs adequate supplies of vitamin D in order for it to absorb the calcium that you eat or drink in your diet.Ī mild lack of calcium and vitamin D may not cause symptoms but it can result in an increased risk of 'thinning' of the bones ( osteoporosis). Foods that contain vitamin D are oily fish (such as sardine, herring, salmon and tuna) and eggs. Vitamin D is mostly made in your skin by exposure to sunlight but you also get some from your diet. (Ergocalciferol is also called vitamin D 2 or calciferol) Ĭalcium and vitamin D are both important for healthy, strong bones. To promote healthy bones and to prevent osteoporosis
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